Accession number (gi) Protein name Commonname Mascot score SILAC ratio RSDa
94721250 VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa VAPA 275 2.75 5.02
167466173 heat shock 70kDa protein 1A HSPA1A/HSPA1B 558 1.84 8.41
24307969 cytoplasmic FMR1 interacting protein 1 CYFIP1 171 1.65 16.83
4504041 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 GNAI2 128 1.65 8.10
4757756 annexin A2 ANXA2 144 1.55 4.24
4826898 profilin 1 PFN1 46 1.51 16.24
28557709 phosphoribosyl pyrophosphate synthetase 1-like 1 PRPS1L1 74 1.50 1.86
9910382 translocase of outer mitochondrial membrane 22 homolog TOMM22 119 1.47 1.44
4557797 non-metastatic cells 1, protein (NM23A) expressed in NME1 189 1.42 12.59
14141152 heterogeneous nuclear ribonucleoprotein M HNRNPM 548 1.36 2.28
5901922 cell division cycle 37 homolog CDC37 151 1.34 11.49
38570062 golgi to ER traffic protein 4 homolog GET4 52 1.35 0.77
22749415 STT3, subunit of the oligosaccharyltransferase complex, homolog A STT3A 90 1.35 18.66
4504279 H3 histone, family 3B (H3.3B) H3F3A/H3F3B 83 1.34 0.29
42558250 cell cycle associated protein 1 CAPRIN1 98 1.33 3.43
4501857 acyl-CoA dehydrogenase, long chain ACADL 89 1.33 0.06
20149560 syntaxin 4 STX4 35 1.32 1.03
33519426 thioredoxinreductase 1 TXNRD1 208 1.31 5.53
4503519 eukaryotic translation initiation factor 3, subunit F EIF3F 314 1.30 8.40
8923390 coiled-coil-helix-coiled-coil-helix domain containing 3 CHCHD3 52 1.30 11.51
4503729 FK506 binding protein 4, 59kDa FKBP4 195 1.30 15.51
4759302 VAMP (vesicle-associated membrane protein)-associated protein B and C VAPB 189 -1.32 8.29
23397429 eukaryotic translation initiation factor 3, subunit M EIF3M 264 -1.32 11.31
4503523 eukaryotic translation initiation factor 3, subunit D EIF3D 154 -1.32 17.54
71773329 annexin A6 ANXA6 296 -1.33 15.72
18379349 vesicle amine transport protein 1 homolog VAT1 416 -1.35 12.77
4501867 aconitase 2, mitocondrial ACO2 124 -1.37 18.76
148491070 CTP synthase CTPS 171 -1.37 14.43
223468663 aldo-ketoreductase family 1, member B10 (aldose reductase) AKR1B10 97 -1.41 10.77  
13491174 MARCKS-like 1 MARCKSL1 122 -1.43 17.02
148727247 ubiquitin specific peptidase 5 (isopeptidase T) USP5 96 -1.43 12.95
4757732 apoptosis-inducing factor, mitochondrion-associated, 1 AIFM1 131 -1.45 4.65
112363070 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 HSPBP1 61 -1.47 19.94  
91807122 annexin A8-like 2 ANXA8L2 497 -1.52 16.28
24308514 glutathione S-transferase alpha 5 GSTA5 57 -1.52 10.70
109134349 coatomer protein complex, subunit gamma 2 COPG2 132 -1.52 5.84
4506619 ribosomal protein L24 RPL24 71 -1.54 8.89
4503243 cytochrome P450, family 51, subfamily A, polypeptide 1 CYP51A1 355 -1.54 7.32
100913206 DEAH (Asp-Glu-Ala-His) box polypeptide 9 DHX9 179 -1.54 17.86
62241042 glutamyl-prolyl-tRNAsynthetase EPRS 95 -1.61 17.68
5453990 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) PSME1 435 -2.27 11.86
aRelative standard deviation
Table 1: Differentially expressed proteins in HepG2 Cells after exposure with 1 μg ml-1 of Ch-SeNPs.