Group Epidermis (μm) Dermis (μm) Number of fibroblasts Number of leukocytes Average SD Average SD Average SD Average SD S 32.92 1.66 1136.76 37.20 12.47 2.30 2.6 1.65 AO 35.56 5.79 1097.83 47.64 12.27 2.30 1.87 1.53 AO3F 30.24 3.63 1014.82 66.79 12.67 2.59 0.27 0.52 C+ 37.58 3.00 1269.11 53.04 7.83 1.68 6.10 3.00 C- 23.95 1.62 672.95 51.48 9.10 1.65 0.67 0.88

Table 2: Thickness of the epidermis and dermis (μm). Number of fibroblasts and leukocytes in 250 μm2 of the papillary dermis in each experimental group. Key: (S) PPG- 5-CETETH-20, (AO) oleic acid, (AO3F) fluconazole-loaded tested formulation, (C+) positive control, (C-) negative control, (SD) standard deviation.