| |
Z-COTE |
|
Namstm |
HP1 |
NIAX |
| |
Coating |
None |
None |
Triethoxycaprylylsilane |
Dimethoxydiphenylsilane/triehoxycaprylyisilane crosspolymer |
| Powder# |
Batch raimber |
EHDA3001 |
4051 |
CNHE0602 |
FCHE1301 |
| Primary particle size (TEM, nm, # measurements in parenthis |
Width: 44 ± 2 (260) |
Diameter: 25 ± 1 (238) |
Width: 28 ± 2 (201) |
Width: 36 ± 2 (300) |
| Length: 73 ± 4 (142) |
|
Length: 96 ± 6 (93) |
Length: 95 ± 5 (94) |
| Specific surface area (BET, m2/g) |
13 ± 2 |
30 ± 3 |
14.9 ± 0.5 |
12 ± 1 |
| In H20# |
Superoxide radical generation (% negative control) |
Dark: 800 ± 300* |
Dark: 280 ± 80 |
Dark: 220 ± 40 |
Dark: 170 ± 50 |
| Light: 12,000 ± 3,000* |
Light: 2,000 ± 400 |
Light: 4,000 ± 700 |
Light: 4,000 ± 300 |
| Endotoxin |
BD |
BD |
BD |
BD |
| Hydrodynamic particle size (DLS, nm, PDI in parenthesis) |
0-time: 410 (0.3) |
0-time: 600 (0.6) |
0-time: 240 (0.3) |
0-time: broad (1) |
| Zeta potential (mV) |
0-time: 27 |
0-time: 9 |
0-time: -10 |
0-time: -7 |
| Altered pH (relative to H2O only) |
0-time: -0.1 |
0-time: 0.0 |
0-time: -0.1 |
0-time: -0.1 |
| In complete cell culture medium (HM-5201) |
Hydrodynamic particle size (DLS, nm, PDI in parenthesis) |
0-time: 260 (0.3) |
0-time: 25 (0.7) |
0-time: 300 (0.6) |
0-time: 90 (0.2) |
| 2h: 100 (0.8) |
2h: 45 (0.8) |
2h: 230 (0.4) |
2h: 35 (0.7) |
| 6h: 260 (0.3) |
6h: 180 (0.2) |
6h: 70 (0.7) |
6h: 340 (0.4) |
| 24h: 90 (0.2) |
24h: 125 (0.3) |
24h: 110 (0.2) |
24h: 360 (0.5) |
| Particle size distribution (DCS, nm) |
0-time: 90-500 |
0-time: ND |
0-time: 20-900+ |
0-time: 400-900+ |
| Zeta potential (mV) |
0-time: 8 |
0-time: 7 |
0-time: -10 |
0-time: -6 |
| 2h: -7 |
2h: -7 |
2h: -7 |
2h: -6 |
| 6h: -7 |
6h: -6 |
6h: -7 |
6h: -6 |
| 24h: -6 |
24h: -7 |
24h: -7 |
24h: -6 |
| Altered pH over 24 h (relative to media only) |
0-time: 0.0 |
0-time: 0.0 |
0-time: 0.0 |
0-time: 0.0 |
| 2h: 0.0 |
2h: 0.0 |
2h: 0.0 |
2h: -0.2 |
| 6h: 0.0 |
6h: 0.0 |
6h: 0.0 |
6h: +0.1 |
| 24h: -0.1 |
24h: 0.0 |
24h: 0.0 |
24h: 0.0 |
|
