Figure 2: Structure of the CMS nanotransporter unimer. A, Scheme showing the dendritic polyglycerol amine (polar core), the alkyl chain (nonpolar inner shell) and the monomethoxy poly(ethylene glycol) (mPEG, hydrophilic outer shell). B, Total structure of the chemical available nanotransporter (polar core: radius 3-5 nm, inner shell 3-5 nm, outer shell 3-4 nm). C, Cone-shaped substructure of the simplified nanotransporter with mPEG outer shell (core radius 2 nm, inner shell and outer shell 1.5-2 nm, respectively). D, Cone-shaped substructure of the optimized nanotransporter with a glutamate outer shell (core radius 1-2 nm, inner shell radius 1.5-2 nm).