Table 1

Cargo	Nile red			Morphine			Morphine-H+
Compartment	DG	DH	-TDS	DG	DH	-TDS	DG	DH	-TDS
Outer Shell	31.3	31.5	-0.2	51.7	52.2	-0.5	43.4	43.8	-0.3
Inner Shell	29.5	29.8	-0.2	41.6	41.9	-0.3	44.5	44.7	-0.2
Core	31.2	31.4	-0.2	48.2	48.7	-0.4	42.8	43.2	-0.3

Table 1: Energy differences (kJ/mol) for guest molecules in CMS nanotransporters with mPEG outer shell. Lower differences in free energy (ΔG), inner energy (ΔH), and entropy (TΔS) indicate higher loading in the compartments of the simplified CMS nanotransporters.