Table 1

SiO₂ NP	Hydrodynamic diameter (nm)b				Polydispersity index (PdI)			Zeta (mV)
SiO₂ NP	water	RPMIc	RPMIc 24h	RPMI (10% FCS)	water	RPMIc	RPMI (10% FCS)	water
15 nm	42.7±0.9	41.3±1.3	226.9±3.4	70.8±0.3	0.40±0.03	0.39±0.03	0.61±0.01	-28.1±0.7
60 nm	67.9±0.7	68.8±1.0	325.2±6.6	158.2±3.0	0.05±0.01	0.05±0.01	0.48±0.01	-30.6±1.2
200 nm	176.5±3	124.0±2	276.5±3.0	148.1±2.5	0.19±0.02	0.02±0.01	0.34±0.03	-31.8±1.6

^aAll measurement were performed at 25 ºC at 100 μg/mL.
^bHydrodynamic diameter was determined as Z-average (% intensity), which was derived from the cumulant mean of the intensity autocorrelation function.
^cThe hydrodynamic diameters were measured in serum-free RPMI medium.

Table 1: Physicochemical characterization of SiO₂ NPa