Variables Code Levels
1 2
Cross Linker X1 0.5 gm 1gm
Drug X2 20 mg 50 mg
Formula code X1 X2 Responses
Particle diameter PDI Zeta Potential Entrapment efficiency (%)a
F1 0.5 20 28.21 0.269 -12.2 66.07
F2 0.5 50 15.69 0.423 -35.9 74.24
F3 1 20 24.36 0.608 -10.6 80.48
F4 1 50 15.69 0.318 -7.67 91.31
aAverage of three experiments
Table 2: Experimental condition, design and responses of 22 factorial design preparation of ACV nanoparticles.