Figure 7: Effect on gross tumor volume regression following intratumoral injection of the nanoparticles associated with IGF-1R/Bcl-2 siRNAs plus p53 plasmid in presence or absence of paclitaxel. The mice bearing 4T1-induced mammary tumor were treated with 100 μl of the particle suspension originally formulated in 1 ml of DMEM with 7 mM of Ca2+ in presence or absence of 800 nm of each of the siRNAs plus 100 ng of p53 and/or 100 nM of paclitaxel, through intratumoral injection and the tumor volumes were estimated according to the modified ellipsoidal formula: 1/2(length×width2).