Figure 4: Fenretinide (HPR) concentrations obtained in mouse plasma after administration of HPR-NC3 (E/D=3) nanocapsules or the reconstructed content of the NCI capsules. Athymic nude mice were orally administered at the dose of 100 mg/kg (n=5) or at the dose of 200 mg/kg (n=5) once a day. The administrations were carried out 1 day or 5 days. Animals were sacrificed 4 h after the last dose and blood was collected from a cardiac puncture.