Rectal V10 Gy V30 V50 V55 V60 V65 V70 V75 Low HI 0.7798 0.4117 0.2403 0.2111 0.1839 0.157 0.1284 0.0938 Standard Error 0.01138 0.0141 0.00947 0.00826 0.00722 0.0062 0.00522 0.00469 High HI 0.7976 0.4411 0.2752 0.2425 0.21215 0.1816 0.149 0.1074 Standard Error 0.0122 0.0165 0.0119 0.0103 0.00893 0.00757 0.00653 0.00603 Dose Reduction 2% 7% 13% 13% 13% 14% 14% 13%   Bladder V10 Gy V30 V50 V55 V60 V65 V70 V75 Low HI 0.8005 0.4604 0.2804 0.2524 0.2271 0.2027 0.1772 0.1469 Standard Error 0.0213 0.018 0.0138 0.0129 0.0121 0.0112 0.0102 0.00923 High HI 0.7948 0.4751 0.2985 0.2689 0.2418 0.2151 0.1867 0.1504 Standard Error 0.0237 0.019 0.0147 0.0137 0.0128 0.0117 0.0105 0.00932 Dose Reduction -1% 3% 6% 6% 6% 6% 5% 2%

Table 2: Rectal and Bladder dose/volume reductions noted as a function of target heterogeneity specifically, rectal V50, V55, V60, V65, V70; HI=Heterogeneity Index, VxGy=Percent of organ volume receiving xGy +/-standarad error.