No BT 1 BT 4 Pts GTVPET CTVstandard CTVPET-influenced   Volume*PET Group GTVPET CTVstandard CTVPET-influenced   Volume*PET Group 1 16 32.4 16,0 16,4 (67,8%) 8.0(24.7%) A 18.8 30,2 18.8 11,4 (46,5%) 6.2(20.5%) A 2 10.8 25.1 10,8 14,3 (79.7%) 9.5(37.8%) A 3.4 22,2 18.8 3,4(16,6%) 2.9(13.1%) C 3 86.4 52.3 57,1 -4,8 (-8,8%) 65.5 (125%) E 15.6 33.3 - - 13.8 (41.4%) C 4 25.1 27 25,9 1,1 (4,2%) 15.8 (58.5%) C 7.5 25,4 24 1,4(5,7%) 1.8(7.1%) D 5 3.1 17.4 10,4 7,0 (50,4%) 1.3(7.5%) D 0.8 20,4 16.4 4,0(21,7%) 0 (0%) D 6 0 18.8 - - 0 (0%) F 0 22,2 - - 0 (0%) F 7 0 25.3 - - 0 (0%) F 0 33,6 - - 0 (0%) F 8 2.7 31.7 20,8 10,9 (41,5%) 1.2(3.8%) B 1.8 27,1 21 6,1(25,4%) 1.4(5.2%) B 9 1.7 26.1 26,9 -0,8 (-3,0%) 0.5(1.9%) D 0.3 22,3 24.7 -2,4 (-10,2%) 0 (0%) D 10 7.5 15.9 18,8 -2,9 (-16,7%) 6.9(43.4%) A 1.5 24,7 13.3 11,4 (60,0%) 1.5(6.1%) C 11 1.2 29.3 22,3 7,0 (27,1%) 0.1(0.3%) D 0.9 20,5 29 -8,5 (-34,3%) 0.5(2.4%) D 12 3.9 23.9 23,3 0,6 (2,5%) 1.4(5.9%) C 0.5 21,5 16.9 4,6(24,0%) 0 (0%) D 13 6.7 25.6 18,7 6,9 (31,2%) 4.3(16.8%) C 0.8 20,6 19.1 1,5(7,6%) 0.6(2.9%) B

Table 3: Volume (ml) of GTVPT, CTVstandard and CTVPET-influenced observed at first and fourth fraction of brachytherapy treatment (BT1 and BT4), differences (%) between CTVstandard and CTVPET-influenced (absolute value in ml and percentage normalized at the average value of two CTVs) and Volume*PET (absolute value in ml and percentage normalized at CTVstandard), that is the volume of GTVPET that does not intersect with CTVstandard.