| |
WBC |
| |
Quartile 1 |
Quartile 2 |
Quartile 3 |
Quartile 4 |
| Outcome event |
HR |
195% CI |
P |
HR |
95% CI |
P |
HR |
95% CI |
P |
HR |
95% CI |
P |
| Anadjusted |
1 |
- |
- |
1.77 |
0.58-5.40 |
0.3185 |
3.86 |
1.44-10.33| |
0.0073 |
6.79 |
2.58-17.83 |
0.0001 |
| Adjusted for demographics |
1 |
- |
- |
1.71 |
0.56-5.23 |
0.3493 |
1.71 |
0.56-5.23 |
0.0106 |
3.65 |
1.35-9.84 |
<0.0001 |
Adjusted for demographics
and risk factors* |
1 |
- |
- |
1.58 |
0.51-4.92 |
0.4263 |
3.81 |
1.39-10.43 |
0.0091 |
7.01 |
2.65-18.55 |
<0.0001 |
Adjusted for above and sICH
severity** |
1 |
- |
- |
0.61 |
0.18-2.05 |
0.4218 |
1.74 |
0.62-4.91 |
0.2922 |
1.31 |
0.44-3.86 |
0.6275 |
Adjusted for above and CRP
quartiles |
1 |
- |
- |
0.67 |
0.20-2.26 |
0.5201 |
2.18 |
0.76-6.21 |
0.1464 |
1.23 |
0.41-3.68 |
0.7079 |
| |
CRP |
|
|
|
|
|
|
|
|
|
|
|
| Outcome event |
HR |
(95% CI) |
P |
HR |
(95% CI) |
P |
HR |
(95% CI) |
P |
HR |
(95% CI) |
P |
| Anadjusted |
1 |
- |
- |
1.39 |
0.61-3.17 |
0.4380 |
1.61 |
0.71-3.64 |
0.2543 |
1.59 |
0.70-3.60 |
0.2658 |
| Adjusted for demographics |
1 |
- |
- |
1.36 |
0.59-3.12 |
0.4694 |
1.66 |
0.73-3.76 |
0.2276 |
1.59 |
0.70-3.59 |
0.2694 |
Adjusted for demographics
and risk factors* |
1 |
- |
- |
1.25 |
0.54-2.87 |
0.6060 |
1.48 |
0.64-3.40 |
0.3550 |
1.46 |
0.64-3.34 |
0.3659 |
Adjusted for above and sICH
severity** |
1 |
- |
- |
1.48 |
0.63-3.48 |
0.3661 |
1.10 |
0.46-2.66 |
0.8280 |
2.33 |
0.97-5.56 |
0.0572 |
Adjusted for above and
WBC count quartiles |
1 |
- |
- |
1.90 |
0.78-4.64 |
0.1604 |
1.44 |
0.59-3.55 |
0.4239 |
2.83 |
1.14-7.05 |
0.0254 |
ICH score. Legend for table: Demographics: age (per 10-year increase) and sex. Risk factors: arterial hypertension, diabetes mellitus, glucose concentration (per 1.0
mmol/l increase) at admission, smoking status and alcohol abuse. sICH severity: oICH scores (per 1-point increase) and sICH hematoma volume (per 1 cc increase)
*This model included interaction terms between smoking status and diabetes mellitus, and between diabetes mellitus and glucose concentration at admission, to satisfy
proportionality assumptions. **This model included interaction terms between oICH scores and sICH hematoma volume to satisfy proportionality assumptions. The
quartiles of WBC are divided as follows: quartile 1: 3.4 to 6.5 x109/l; quartile 2: 6.6 to 7.9 x109/l, quartile 3: 8.0-9.9 x109/l, quartile 4: >9.9. The upper limit of the WBC
measurement was 21.0 x109/l. The quartiles of CRP are divided as follows: quartile 1: 0.8 to 5 mg/l; quartile 2: 5.1 to 9.0 mg/l, quartile 3: 9.1 to 17.1, quartile 4: 17.1 mg/l
or greater. The upper limit of the CRP measurement was 96 mg/l. |
