| Treatment groups |
Drug name |
Total duration of convulsion (Sec) |
% change from control (Convulsive time) |
Mortality (%) |
Protection (%) |
Significance |
| I |
10% DMSO |
213.50 |
100 |
83.3 |
16.7 |
Nil |
| II |
Gabapentin |
279.00 |
30.7 |
33.3 |
66.7 |
P<0.05 |
| III |
A-350619 |
196.40 |
8.0 |
83.3 |
16.7 |
NS |
| IV |
Methylene blue |
360.06 |
69.2 |
16.7 |
83.3 |
P<0.01 |
| V |
BRL50481 |
220.43 |
3.2 |
66.7 |
33.3 |
NS |
| VI |
A-350619 + BRL50481 |
230.31 |
8.2 |
83.3 |
16.7 |
NS |
| VII |
Methylene blue + BRL50481 |
276.12 |
29.8 |
33.3 |
66.7 |
P<0.05 |
The group of mice (n=6) were injected with 60 mg/kg, i.p of PTZ for induction of convulsion and the total convulsive time was estimated. A value of P<0.05 was considered significant Vs DMSO group, NS= P > 0.05. All the drugs were administered intraperitoneally. The drugs used were administered in the following doses. DMSO (5 ml/kg, i.p), gabapentin (2.5 mg/kg, i.p), A-350619 (100 μM/kg, i.p), methylene blue (50 mg/kg, i.p) and BRL50481 (2 mg/kg, i.p). (One way ANOVA followed by Dunnett’s test compared with DMSO treated mice) |
