Groups Parameters CONTROL  13 days before CMS CMS+CFA D39 of CMS CMS D39 of CMS
Open arms entries 37,37 ± 7,686 28,68 ± 3,84* 17,87 ± 2,68***
Open arms duration (sec) 115,18 ± 22,669 110,00 ± 11,33 70,37 ± 12,93**
Open arms returns 0,31 ± 0,602 0 NS 0 NS
Closed arms entries 47,24 ± 3,80 31,57 ± 1,605** 23,62 ± 2,438***
Closed arms duration (sec) 147,31 ± 23,2 142,43 ± 54,058* 155,62 ± 47,074***
Closed arms returns 1,685 ± 0, 623 0* 0*
Center entries 17,50 ± 5,428 15,00 ± 3,265 NS 13,87 ± 3,907*
Center duration (sec) 25,12 ± 7,246 36,43 ± 15,988** 40,12 ± 18,473**
Head dipping frequency 16,81 ± 7,909 12,00 ± 6,244* 14,00 ± 4,407*
Rearing frequency 17,44 ± 6,5 14,55 ± 5,68 NS 15,62 ± 7,501 NS
Freezing duration (sec) 0 12,57 ± 9,72*** 28,37 ± 7,82***
NS: Not significant, *Significant (P<0.05), **Highly significant (P<0.01), ***Very highly significant (P<0.001)
Table 3: Parameters variation in Elevated plus maze test (EPM) in Control, CMS and CMS+CFA groups, 13 days before CMS and in D39 of the CMS.