Groups Parameters Control 13 days before CMS CMS+CFA D39 of CMS CMS D39 of CMS
Total distance (cm) 2681,11 ± 1362,217 240,50 ± 58,356*** 227,11 ± 86,128***
Center square entries 10,12 ± 3,854 6,87 ± 3,796* 6,33 ± 3,774*
Periphery entries 22,65 ± 10,289 14,00 ± 6,568** 12,43 ± 6,399**
Border entries 22,65 ± 10,289 9,62 ± 4,438*** 12,33 ±7,745**
Rearing frequency 27,23 ± 6,887 22,75 ± 10,579* 21,22 ±7,102*
Center square duration (sec) 15,59 ± 4,651 12,75 ± 6,713* 12,55 ± 9,862*
Periphery duration (sec) 239,89 ± 25,585 12,00 ± 6,676*** 25,87 ± 21,383***
Border duration (sec) 42,29 ± 18,853 256,50 ± 36,371*** 215,43 ± 73,810***
Locomotion index 102,75 ± 4,856 81,95 ± 32,502** 71,10 ± 31,372**
Freezing duration (sec) 0 59,57 ± 49,812*** 84,87 ± 54,671***
NS: Not significant, *Significant (P< 0.05), ** Highly significant (P<0.01), ***Very highly significant (P<0.001).
Table 4: Variations in the parameters of Open field test in Control, CFA+CMS, and CMS mice 13 days before CMS and in D39 of CMS.