Compound % Control (Compound) % Control (Compound + CSA) % Difference J-147 93.7 92.1 NC Rotenone 80.5 86.1 NC Camptothecin 76.6 85.3 NC

Table 3: Drug P-glycoprotein (PgP) Binding. PgP Interaction Ranking (based on % Difference in the absence and presence of CSA, n=7 replicates). NC=No change.