Measures Criterion for recovery
1. Unified Parkinson’s disease rating scale (MDS-UPDRS) A clinically meaningful reduction in signs and symptoms
2. Changes in medication A meaningful reduction in L-DOPA and other medications aiming to up regulate the dopaminergic system
3. Response to medication Increases in ‘on time’; decreases in ‘off-time’ and drug induced dyskinesias
4. Activities of Daily Living (ADL) Meaningful improvements in the execution of personally and socially relevant tasks
5. Self assessed global change in disease impact Improvement in condition in comparison to baseline
6. Quality of Life (QAL) Self perceived, meaningful increases in health, physical and emotional wellbeing
Table 1: Outcome Measures for Overall Reactivity at end point.