Patients undergoing open Burr hole and craniotomy Patients undergoing neuroendoscopic surgery
  Phase II (40pts) Phase III (98pts) Phase II (4pts) Phase III (15pts)
Mean 1237.1 1283.6 2527.5 1376.0
SD 922.5 1164.5 1014.7 813.2
Maximum 4130.0 8750.0 4000.0 2980.0
Median 1145.0 1000.0 2130.0 1180.0
Minimum 100.0 50.0 1850.0 350.0
pts=patients [Modified and translated with permission from reference [11]].
Table 4: Volume of ARTCEREB administered in phase I and phase III clinical trials (mL).