| |
Baseline (N=98) |
Week 24 (N=96) |
Week 48 (N=94) |
Week 72 (N=89) |
Week 96 (N=80) |
| Depression (BDI):*,† |
|
|
|
|
|
| Depression categories, n (%): |
|
|
|
|
|
| Ups and downs considered normal (BDI scores 1-10) |
65 (66.3) |
64 (66.7) |
61 (67.0) |
70 (80.5) |
63 (78.8) |
| Mild mood disturbance (BDI scores 11-16) |
20 (20.4) |
19 (19.8) |
18 (19.8) |
6 (6.9) |
7 (8.8) |
| Borderline clinical depression (BDI scores 17-20) |
10 (10.2) |
6 (6.3) |
5 (5.5) |
4 (4.6) |
7 (8.8) |
| Moderate depression (BDI scores 21-30) |
3 (3.1) |
6 (6.3) |
5 (5.5) |
7 (8.0) |
3 (3.8) |
| Severe depression (BDI scores 31-40) |
0 (0.0) |
1 (1.0) |
2 (2.2) |
0 (0.0) |
0 (0.0) |
| Extreme depression (BDI scores >40) |
0 (0.0) |
0 (0.0) |
0 (0.0) |
0 (0.0) |
0 (0.0) |
| Overall depression (BDI scores ≥17), n (%) |
13 (13.3) |
13 (13.5) |
12 (13.2) |
11 (12.6) |
10 (12.5) |
| Mean BDI scores (SD) |
8.8 (6.3) |
8.5 (7.1) |
8.5 (7.4) |
7.6 (6.7) |
7.4 (6.1) |
| Sexual dysfunction (MSISQ-19), n (%):‡, §, ǁ |
|
|
|
|
|
| Primary sexual dysfunction** |
31 (32.6) |
27 (29.0) |
27 (30.7) |
21 (25.3) |
23 (30.7) |
| Secondary sexual dysfunction** |
21 (22.1) |
17 (18.3) |
15 (17.0) |
12 (14.5) |
18 (24.0) |
| Tertiary sexual dysfunction** |
17 (17.9) |
11 (11.8) |
13 (14.8) |
7 (8.4) |
4 (5.3) |
| Overall sexual dysfunction |
43 (45.3) |
36 (38.7) |
34 (38.6) |
27 (32.5) |
31 (41.3) |
| Work absenteeism: |
|
|
|
|
|
| Patients missing at least one day from work, n (%):††,‡‡,§§,ǁǁǁ |
46 (52.9) |
27 (30.3) |
19 (22.9) |
22 (26.5) |
18 (25.4) |
| Mean number of working days missed (SD)***, †††, *, † |
45.8 (56.5) |
40.6 (63.5) |
21.6 (44.9) |
42.3 (51.7) |
38.9 (66.1) |
| Causes for work absenteeism, n (%):‡‡‡ |
|
|
|
|
|
| Multiple sclerosis signs |
26 (56.5) |
15 (55.6) |
10 (52.6) |
12 (54.5) |
12 (66.7) |
| Disease relapse |
16 (34.8) |
8 (29.6) |
3 (15.8) |
6 (27.3) |
5 (27.8) |
| Other |
11 (23.9) |
5 (18.5) |
8 (42.1) |
7 (31.8) |
1 (5.6) |
*Missing data at week 48, n=3; †Missing data at week 72, n=2;
‡Missing data at baseline and week 24, n=3; §Missing data at weeks 48
and 72, n=6; ǁMissing data at week 96, n=5; **One patient may be
included in more than one of the following categories: primary sexual
dysfunction, secondary sexual dysfunction and tertiary sexual
dysfunction; ††Missing data at baseline and week 48, n=11; ‡‡Missing
data at week 24, n=7; §§Missing data at week 72, n=6; ǁǁǁMissing data at
week 96, n=9; ***Missing data at baseline, n=3; †††Missing data at week
24, n=4; ‡‡‡Multiresponse variable over patients missing at least one
day from work.
BDI: Beck’s Depression Inventory; MSISQ-19: Multiple Sclerosis
Intimacy and Sexuality Questionnaire-19; SD: standard deviation. |
