Figure 3: Athymic rats show attenuated asymmetric forelimb recovery by Cylinder Tests after unilateral 6-OHDA intrastriatal lesion of the nigro-striatal dopaminergic pathway. At 4 and 8 weeks post unilateral 6-OHDA lesion we used the Cylinder test to determine preferential paw. At 4 weeks post lesion RNU-/- and RNU-/+ showed a significant preferential right paw use as compared to non-surgery controls RNU-/- (%60.87 -/+ 9.249 vs. %84.91 -/+ 5.814; *, P = 0.026); RNU-/+ (48.69 -/+ 5.618 vs. 85.94 -/+ 4.685; *, P = 0.0002) (A). At 8 weeks post saline RNU-/- showed significant right paw preference as compared to 4 wks post saline (%54.81 -/+ 6.614 vs. 79.60 -/+ 9.261; *, P = 0.0236) (B). At 8 weeks post 6OHDA lesion RNU -/+ showed a trend towards recovery from right paw preference (%57.94 -/+ 14.49 vs. 85.94 -/+ 4.685; P = 0.069), while RNU-/- shows no significant change in right paw use (%72.54 -/+ 8.286 vs. 84.91 -/+ 5.814; P = 0.2529). Error bars equal SEM (*, P<0.05).