Figure 5: Athymic rats exhibit greater D-Amphetamine-induced rotational behavior following unilateral 6-OHDA striatal lesion of the nigro-striatal pathway. Two weeks afterunilateral 6-OHDA lesioned (right) RNU-/- rats show a trend towards increased rotational behavioral ipsilateral to the lesion (right) after damphetamine sulphate administration as compared to RNU-/+ rats (1064 -/+ 203.4, N=5 vs. 685.4 -/+ 151.7, N=8; *, P = 0.071) (A). At six weeks post-lesion there was a significant increase in RNU-/- rotational behavior as compared to RNU-/+rats (1188 -/+ 306.5, N=5 vs. 622.8 -/+ 129, N=8; *, P = 0.037) (B). Error bars equal SEM (*, p=0.05).