Group I Mean immobility time (sec) ± S.E.M.
Vehicle control 214 ± 23.60
rH-Epo (250 IU/kg, s.c.) 212.2 ± 21.68
Venlafaxine (2mg/kg). 202.4 ±25.85
Imipramine (2.5 mg/kg) 199 ± 22.13
Fluoxetine (5 mg/kg) 201 ± 21.37
Clorgyline        (0.125 mg/kg) 213 ±15.11
rH-Epo ( 250 IU/kg) ±venlafaxine (2 mg/kg) 82 ±8.51***
rH-Epo (250 IU/kg) ±Imipramine (2.5 mg/kg) 113.33±10.05***
rH-Epo (250 IU/kg) ±Fluoxetine (5 mg/kg) 96.5 ±20.44***
rH-Epo ( 250 IU/kg) ±Clorgyline (0.125 mg/kg) 154.17 ±22.23***
Group II
Vehicle control 186.33 ±1.34
rH- EPO(1000 IU/kg, s.c.) 92 ± 1.48***
Pindolol (10mg/kg) 183.33 ± 1.42
Clonidine(0.15 mg/kg) 212±2.14***
rH-Epo(1000 IU/kg) ± Pindolol (10mg/kg ) 212± 3.56***
rH-Epo (1000 IU/kg) ±Clonidine . (0.15 mg/kg) 138.66± 3.99***
Group III
Vehicle control 204.66±4.63
Haloperidol (2mg/kg) 311.83 ± 2.35***
rH-Epo (1000IU/kg )±Haloperidol (2mg/kg) 259.16±4.67***
Yohimbine (10mg/kg) 203.8±8.51
rH-Epo (250 IU/kg)±Yohimbine (10mg/kg) 155.66±4.84***
Table 1: Effect of pretreatment of rH-Epo on sub therapeutic doses of standard antidepressants/drugs in tail suspension test of mice