A Day 1 Day 3 Day 5 Day 7 Day 9 Day 11 Day 13 Day 15 Day 17 Day 19 t–values: 8.80* 12.32* 8.47* 10.49* 14.49* 12.87* 13.99* 12.41* 9.00* 9.00* AD                     Mean 8.73 8.13 8.53 5.63 8.03 5.33 5.57 5.37 6.43 7.40 SD 6.65 4.90 7.10 5.35 5.97 5.23 5.84 5.60 5.49 7.39 Control                     Mean 19.60 19.53 19.63 19.70 19.63 19.60 19.57 19.80 19.33 19.70 SD 1.25 1.28 1.00 1.15 1.00 1.30 1.17 0.76 1.52 1.15 B Day 1 Day 3 Day 5 Day 7 Day 9 Day 11 Day 13 Day 15 Day 17 Day 19 t–values: 8.68* 11.20* 6.90* 7.14* 12.06* 7.65* 6.50* 7.02* 7.73* 9.00* AD                     Mean 7.83 6.33 5.10 4.30 6.17 3.87 5.57 3.80 4.10 4.93 SD 4.85 3.03 3.95 3.19 2.72 2.62 5.84 2.86 2.71 2.89 Control                     Mean 0.10 0.10 0.10 0.07 0.13 0.13 0.10 0.10 0.20 0.13 SD 0.55 0.31 0.40 0.64 0.35 0.51 0.40 0.40 0.55 0.43

Table 5: Pairwise differences (Student’s t-test) between AD patients and controls for: (i)4A: writing-time (min), (ii)4B: dΔ, over 10 days of testing (Days 1, 3, 5, 7, 9, 11, 13, 15, 17 and 19). *versus control group, Student’s t-test (df=1, 58), p<0.0001.