Variable β OR (95% CI) p value Age at onset 0.072 1.07 (1.00-1.15) 0.046 Gender 0.127 1.13 (0.47-2.70) 0.77 HLA DRB1*08 1.214 0.25 (0.06-0.92) 0.03 OCB -1.649 1.37 (0.61-3.08) 0.4 IgG index 0.893 2.41 (0.31–18.9) 0.39 Disease duration 0.076 1.08 (1.01-1.13) 0.005

Table 3: Odds to convert from relapsing remitting to progressive multiple sclerosis course (Logistic regression model with HLA DRB1*08 allele; β (beta) – regression coefficient, OR – odds ratio, 95% CI – confidence interval, OCB – oligoclonical bands, IgG index - immunoglobulin G index.