Figure 3: Right hemispheric lesions associated with non-agitated confusion, hyperactive delirium, and secondary mania. Agitated and non-agitated confusional states share overlapping cortical and subcortical neural substrates including posterior parietal, prefrontal, and related subcortical connections. Hyperactive delirium and secondary mania share overlapping cortical and subcortical neural substrates including medial temporal and paralimbic cortices. Secondary mania is particularly associated with orbitofrontalsubcortical circuit lesions.