Baseline variables

HFrEF (LVEF<40%; n=1540)

HFpEF (LVEF>50%; n=880)

p-value

Mean LVEF, %

25.9

62.4

<0.001

Age, y

71.8 ± 12

75.4 ± 11.51

<0.001

Female (%)

37.4

65.7

<0.001

Coronary artery disease (%)

48.7

35.5

<0.001

Angina (%)

28.0

22.8

<0.005

Prior myocardial infarction (%)

39

16.6

<0.001

Prior CABG (%)

12.9

5.8

<0.001

Hypertension (%)

84

91

<0.001

Diabetes (%)

38.9

31.7

<0.001

Atrial fibrillation (%)

23.6

31.8

<0.001

COPD (%)

13.2

17.7

<0.002

Hemoglobin <10g/dL

9.9

21.1

<0.001

Systolic BP, mmHg

146

156

<0.001
LVEF, left ventricular ejection fraction; CABG, coronary artery bypass grafting; COPD, chronic obstructive pulmonary disease.
Table 1: Characteristics of patients with heart failure and reduced ejection fraction versus heart failure with preserved ejection fraction. Adapted from Bhatia et al. [5].