| Author |
Patients |
Type of study |
Intervention |
n |
Main results |
| Bates(1989) |
RRMS |
RCT, double blind parallel design; |
EPA 1.71/DHA 1.14g/day
vs.
Oleic acid 7.2g/day |
145
147 |
No Significant effect on relapse rate and disabilityprogression. Positive trend
In fish oil group |
| Weinstock-Guttmann
(2005) |
RRMS |
RCT, double blind parallel design; 12 month follow-up. IMT allowed |
EPA 1.98/DHA 1.32 g/day+dietary fat restriction
Vs.
Olive oil 6 g/day+dietary fat restriction |
13
14 |
No effect on relapse rate or disability. Positive effect
on mental and physical health related to quality of life in fish oil group |
| Torkildsen (2012) |
RRMS |
RCT, double blind parallel design; 24 month follow-up |
EPA 1.35/DHA 0.85 g/day
vs.
Corn oil 5 g/day |
46
46 |
No effect of ω-3 PUFAs on MRI-activity,relapse rate or disability progressionneither as monotherapynor as add-on to IFN-β |
| Pantzaris (2013) |
RRMS |
RCT, double blind parallel design; 30 month follow-up |
EPA 1.65/DHA 4,65 g/day GLA 2.0/LA 3.85 g/day+vit A, vit E, γ-tocopherol (0.6, 22, and 760 mg/day)
vs.
Olive oil 16.9 g/day |
20
20 |
Significant reduction of the annual relapse rate and disability progression |
