Figure 2: COG112 treatment increases the beam-walking and BMS scores in LPC-induced spinal cord demyelination model in mice. A. Representative pictures to show the great improvement in beamwalking following COG112 treatment. B. Beam walking scores, and C. BMS scores were obtained on -1d (before surgery), 3d to 21d (after surgery). The mice were put on the 4 mm beam to walk and recorded with video camera. Note that the forelimbs of the mouse were not affected but the hindlimbs paralysis on the 3rd day while on the 21st day the mouse could hold and stand on the beam with the hindlimbs and keep balance very well. Each value is the mean ± SEM of determinations in 6 mice per group. *, P< 0.05; **, P< 0.01; ***, P< 0.001 in COG112 group relative to Antp group. #, P< 0.05; ##, P< 0.01; ###, P< 0.001 relative to vehicle control.