Disease category Induction therapy Maintenance therapy Localized disease Methotrexate and steroids Low-dose steroids plus azathioprine or leflunomide or methotrexate Early Systemic Methotrexate or cyclophosphamide and steroids Low-dose steroids plus azathioprine Generalized disease Cyclophosphamide and steroids Low-dose steroids plus azathioprine or mycophenolate mofetil Severe disease Cyclophosphamide and steroids plus plasma exchange Low-dose steroids plus azathioprine or mycophenolate mofetil Refractory disease Deoxyspergualin, mycophenolate mofetil, antithymocyte globulin or rituximab No consensus

Table 3: Assessment of Disease category.