Degree of blood pressure control Mean creatinine clearance (ml/ min/1.732 ± SE) P value
  Baseline 5 years  
Hypertensive patients
Intensive 75.0 ± 4.4 56.9 ± 5.8 0.035
Moderate 77.5 ± 5.5 52.6 ± 5.8 0.006
Normotensive patients
Intensive 84.5 ± 7.2 57.7 ± 9.2 0.032
Moderate 76.0 ± 6.3 52.9 ± 9.7 0.042
Table 1: Effect of intensive versus moderate blood pressure control on the renal function of hypertensive and normotensive patients with overt diabetic nephropathy in the ABCD trial (57).