Aptamers: RE31 (blue), 31TBA (yellow), RE25 (red), 15TBA (green) were added in the specified concentrations to human plasma, and thrombin time (A), prothrombin time (B), and aPTT (C) were recorded in the presence of human thrombin. The time of fibrin clot formation has been recorded in all tests. The results of 3-4 reproducible experiments are presented. On the X axis is the aptamer concentration (μM), on the Y axis is the time (seconds).
Figure 2: Effects of RE31, 31TBA, and other aptamers on human plasma clotting formation.