AAP RA No35 AAP RA No18 AAP RA+No17 g GT RA No35 g GT RA-  No18 g GT RA+ No 17 b2 Microglobulin RA No 35 b2 Microglobulin RA-  No 18 b2 Microglobulin RA+  No 17 SENSITIVITY % 68,57 77,77 58,82 45,71 55,55 35,29 0 0 0 SPECIFICITY % 80 80 80 82,85 82,85 82,85 97,14 97,14 97,14 PREDICTIVE VALUES FOR THE POSITIVE TEST % 77,41 66,66 58,82 72,72 62,50 50 0 0 0 PREDICTIVE VALUES FOR THE NEGATIVE TEST % 28,20 2,5 0 39,58 21,62 27,5 89,74 34,61 33,33 PRECISION % 74,28 79,24 73,07 64,28 73,58 67,30 48,57 64,15 65,38

KREATININE SERUM RA No 35 KREATININE SERUM RA- No  18 KREATININE SERUM RA+  No 17 KREATININ URINA RA No 35 KREATININ URINA RA-No 18 KREATININ URINA RA+  No 17 UREA SERUM RA No 35 UREA SERUM RA- No 18 UREA SERUM RA+  No17 SENSITIVITY % 8,57 5,55 11,76 25,71 33,33 17,64 11,42 0 23,52 SPECIFICITY % 94,28 94,28 94,28 85,71 85,71 85,71 97,14 97,14 97,14 PREDICTIVE VALUES FOR THE POSITIVE TEST % 60 33,33 50 64,28 54,54 37,5 80 0 80 PREDICTIVE VALUES FOR THE NEGATIVE TEST % 49,23 34 31,25 46,42 28,57 31,88 47,69 34,61 27,65 PRECISION % 51,42 64,15 67,30 55,71 67,92 63,46 54,28 64,15 73,07

GFR RA No 35 GFR RA- No 18 GFR RA+  No 17 RF RA No 35 RF RA-  No 18 RF RA+ No 17 CRP RA No35 CRP RA- No 18 CRP RA+No17 SENSITIVITY % 40 38,88 41,17 48,57 0 100 66,66 16,66 76,47 SPECIFICITY % 88,57 88,57 88,57 94,28 4,28 94,28 88,57 88,57 88,57 PREDICTIVE VALUES FOR THE POSITIVE TEST % 77,77 63,63 63,63 89,47 0 89,47 77,77 42,85 76,47 PREDICTIVE VALUES FOR THE NEGATIVE TEST % 40,38 26,19 24,39 35,29 35,29 0 40,38 36,60 11,42 PRECISION % 64,28 71,69 73,03 71,42 62,26 96,15 64,28 64,15 84,61

SER RA  No35 SER RA-  No 18 SER RA+ No 17 MORNING RIGID RA No 35 MORNING RIGID RA- No  18 MORNING RIGID RA+ No  17 DAS 28 RA No 35 DAS 28 RA- No18 DAS 28 RA+ No 17 SENSITIVITY % 77,14 72,22 82,35 74,28 77,77 70,58 80 72,22 88,23 SPECIFICITY % 88,57 88,57 8,57 100 100 100 100 100 100 PREDICTIVE VALUES FOR THE POSITIVE TEST % 87,09 76,47 77,77 100 100 100 100 100 100 PREDICTIVE VALUES FOR THE NEGATIVE TEST % 20,51 13,88 8,82 20,45 10,25 12,5 16,16 12,5 5,40 PRECISION % 82,85 83,01 86,53 87,14 92,48 90,38 90 90,56 96,15

ACPA RA  No 35 ACPA RA-  No 18 ACPA RA+ No 17 SENSITIVITY % 65,71 61,11 70,58 SPECIFICITY % 97,14 97,14 97,14 PREDICTIVE VALUES FOR THE POSITIVE TEST % 95,83 91,66 92,30 PREDICTIVE VALUES FOR THE NEGATIVE TEST % 26,08 17,03 12,82 PRECISION % 81,42 84,90 88,46

Table 2: Diagnostic performance of AAP, γGT, β2 M and other laboratory variables in RA.