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Figure 1: (A) Q-PCR analysis for CD44-pan, (B) CD44s, and (C) CD44v3 expression in kidneys of WT (white bars), CD44s- (black bars) and CD44v3-transgenic mice (stacked bars). Data normalized for TBP expression levels. (D) Representative micrographs (x20) of CD44 immunostaining in renal paraffin sections of WT and CD44s- and CD44v3-transgenic mice in sham condition and 24h after LPS-injection. Mean + SEM, n=7-8, *=p<0.05, #=p<0.05 vs sham. |