| Subgroups analysis of
chronic tubulointerstitial injuries |
No. of trials |
Hazard ratio
(95% CI) |
P-subgroup
difference |
| Sample size |
>200 |
3 |
2.87 (1.64, 5.02) |
0.13 |
| <200 |
4 |
6.88 (2.59, 18.25) |
| Follow-up |
>7 years |
4 |
4.36 (2.59, 7.32) |
0.57 |
| < 7 years |
3 |
2.79 (0.65, 11.92) |
| Endpoint |
ESRD
Renal failure |
4 |
2.47 (1.41, 4.34) |
0.05 |
| 3 |
6.91 (2.87, 16.62) |
| Adjustment |
Univariate
Multivariate |
2 |
4.71 (0.70, 31.81) |
0.77 |
| 5 |
1.05 (1.01, 1.09) |
| Baseline eGFR |
<80 ml/min per 1.73 m2
>80 ml/min per 1.73 m2 |
4 |
4.20 (1.12, 15.68) |
0.85 |
| 3 |
3.66 (2.23, 6.01) |
| Percentage of nephrotic syndrome |
100% |
2 |
5.90 (2.23, 15.60) |
0.28 |
| <100% |
5 |
2.99 (1.42, 6.29) |
| Percentage of immunosuppression |
>80% |
4 |
5.99 (3.29, 10.89) |
0.02 |
| <80% |
3 |
2.21 (1.22, 4.00) |
| Country |
North American/Europe |
3 |
2.79 (0.65, 11.92) |
0.57 |
| Asia |
4 |
4.36 (2.59, 7.32) |
|
