Hgb level (g/dl)

rHuEpo dosage

Darbepoetin alfa dosage

Hgb 10.5 or less

6000 IU, 3 times/week

90 ug, once/week

Hgb > 10.5 - < 11.0

6000 IU, 2 times/week

60 ug, once/week

Hgb 11 - 12.0

6000 IU, once/week

30 ug, once every 2 weeks

Hgb > 12.0

Discontinued

Discontinued

*Hgb= hemoglobin
Table 1: Titration protocol of darbepoetin alfa according to Hgb* concentrations.