Before

After

p value

 

Kt/V

1.9

1.8

0.715

WCrCl (L/week/1.732)

66.3+5.8

65.6+4.5

0.313

BUN (mg/dl)

75.7+16.3

74.4+18.2

0.112

Creatinine (mg/dl)

10.8+3.3

11.2+3.8

0.074

Calcium (mg/dl)

8.3+1.1

8.6+0.6

0.279

Phosphorus (mg/dl)

5.5+1.3

5.6+1.2

0.224

Albumin (g/dl) 3.9+1.2 4.1+0.3 0.266
AST (U/L) 21.8+11.2 21.5+11.5 0.823
ALT (U/L) 22.2+12.0 20.8+13.4 0.409

iPTH (pg/ml)

172.4+68.9

169.8+62.3

0.118

WCrCl = weekly creatinine clearance, AST = aspartate aminotransferase, ALT = alanine aminotransferase, iPTH = intact parathyroid hormone
Table 4: Differences in Kt/V, weekly creatinine clearance and serum biochemical parameters before and after use of darbepoetin alfa.