| |
Graft Survival |
Patient Survival |
| Variable |
Full |
Stepwise |
Full |
Stepwise |
| BMI Category |
|
|
|
|
|
|
|
|
| Underweight |
5.383 |
* |
6.159 |
** |
10.168 |
|
1.565 |
|
| Normal |
Reference |
Reference |
Reference |
Reference |
| Overweight |
2.283 |
* |
2.578 |
** |
1.002 |
|
0.942 |
|
| Obese |
2.681 |
* |
2.846 |
** |
0.393 |
|
0.671 |
|
| Morbidly Obese |
4.279 |
* |
4.351 |
** |
2.559 |
|
1.762 |
|
| Extremely Morbidly Obese |
3.434 |
|
2.754 |
|
3.229 |
|
1.551 |
|
| Recipient Characteristics |
|
|
|
|
|
|
|
|
| Gender |
|
|
|
|
|
|
|
|
| Female |
0.812 |
|
|
|
0.520 |
|
|
|
| Race |
|
|
|
|
|
|
|
|
| African American |
1.385 |
|
|
|
0.582 |
|
|
|
| Other |
0.000 |
|
|
|
0.000 |
|
|
|
| White |
Reference |
|
|
Reference |
|
|
| Ethnicity |
|
|
|
|
|
|
|
|
| Hispanic |
3.026E+06 |
|
|
|
1.726E+07 |
|
|
|
| Age (years) |
|
|
|
|
|
|
|
|
| 18 - 30 |
Reference |
|
|
Reference |
|
|
| 31 - 44 |
2.993 |
|
|
|
9.893E+07 |
|
|
|
| 45 - 59 |
2.459 |
|
|
|
5.784E+07 |
|
|
|
| > 60 |
3.613 |
|
|
|
5.141E+07 |
|
|
|
| Primary cause of ESRD |
|
|
|
|
|
|
|
|
| Diabetes mellitus |
2.227 |
|
|
|
47.176 |
|
|
|
| Glomerulonephritis |
0.779 |
|
|
|
1.004 |
|
|
|
| PKD |
1.798 |
|
|
|
4.130 |
|
|
|
| Hypertension |
1.172 |
|
|
|
1.623 |
|
|
|
| Unknown |
20.783 |
* |
|
|
0.000 |
|
|
|
| Other |
Reference |
|
|
Reference |
|
|
| Pre-Transplant Dialysis Duration |
|
|
|
|
|
|
|
|
| None (pre-emptive) |
Reference |
|
|
Reference |
|
|
| 0-12 months |
1.691 |
|
|
|
14.737 |
* |
|
|
| 13-24 months |
1.906 |
|
|
|
20.687 |
* |
|
|
| 25-60 months |
1.784 |
|
|
|
13.530 |
|
|
|
| More than 60 months |
2.325 |
|
|
|
31.123 |
* |
|
|
| Diabetes |
0.402 |
|
|
|
0.028 |
|
|
|
| PVD |
0.878 |
|
|
|
1.226 |
|
|
|
| Donor Characteristics |
|
|
|
|
|
|
|
|
| Gender |
|
|
|
|
|
|
|
|
| Female |
1.855 |
|
|
|
1.069 |
|
|
|
| Race |
|
|
|
|
|
|
|
|
| African American |
0.965 |
|
|
|
0.088 |
|
|
|
| Other |
0.652 |
|
|
|
0.229 |
|
|
|
| White |
Reference |
|
|
Reference |
|
|
| Age (years) |
|
|
|
|
|
|
|
|
| ≤ 18 |
2.052 |
|
|
|
0.915 |
|
|
|
| 19 - 30 |
Reference |
Reference |
Reference |
Reference |
| 31 - 44 |
0.571 |
|
0.482 |
* |
0.363 |
|
|
|
| 45 - 59 |
1.336 |
|
|
|
1.291 |
|
|
|
| ≥ 60 |
0.694 |
|
|
|
0.797 |
|
4.984 |
** |
| BMI category (kg/m2) |
|
|
|
|
|
|
|
|
| ≥ 10 to < 25 |
Reference |
|
|
Reference |
|
|
| ≥ 25 to < 30 |
0.751 |
|
|
|
0.713 |
|
|
|
| ≥ 30 |
0.583 |
|
|
|
0.345 |
|
|
|
| Death due to stroke |
2.405 |
* |
2.716 |
*** |
4.714 |
|
|
|
| Terminal Creatinine ≥ 1.5 |
1.196 |
|
|
|
4.134 |
|
|
|
| Hypertension history |
0.806 |
|
|
|
0.275 |
|
|
|
| Diabetes |
1.864 |
|
|
|
32.789 |
|
|
|
| CMV sero-positive |
4.087E+05 |
|
|
|
2.723E+06 |
|
|
|
| Transplant Factors |
|
|
|
|
|
|
|
|
| Donor type |
|
|
|
|
|
|
|
|
| SCD |
Reference |
|
|
Reference |
|
|
| ECD |
1.475 |
|
|
|
1.622 |
|
|
|
| DCD |
0.549 |
|
|
|
0.265 |
|
|
|
| Peak PRA % |
|
|
|
|
|
|
|
|
| 0-10% |
Reference |
|
|
|
|
|
|
| 11-30% |
0.531 |
|
|
|
0.000 |
|
|
|
| >30% |
0.298 |
|
|
|
0.000 |
|
|
|
| Unknown |
0.404 |
|
|
|
0.000 |
|
|
|
| CMV sero-pairing |
|
|
|
|
|
|
|
|
| Unknown |
0.000 |
|
|
|
0.000 |
|
|
|
| Donor - / Recipient - |
Reference |
Reference |
Reference |
Reference |
| Donor - / Recipient + |
0.000 |
|
1.949 |
* |
0.000 |
|
|
|
| Donor + / Recipient - |
0.673 |
|
|
|
1.901 |
|
|
|
| Donor + / Recipient + |
0.000 |
|
|
|
0.000 |
|
|
|
| HLA Mismatches |
|
|
|
|
|
|
|
|
| 0 HLA mismatches |
Reference |
Reference |
Reference |
Reference |
| 1 HLA mismatches |
7.395 |
|
5.344 |
* |
0.010 |
|
|
|
| 2 HLA mismatches |
0.000 |
|
|
|
0.076 |
|
|
|
| 3 HLA mismatches |
1.925 |
|
|
|
2.253E+07 |
|
|
|
| 4 HLA mismatches |
1.387 |
|
|
|
5.460E+06 |
|
|
|
| 5 HLA mismatches |
1.880 |
|
|
|
1.660E+07 |
|
|
|
| 6 HLA mismatches |
3.451 |
|
|
|
9.818E+07 |
|
3.204 |
* |
| Sensitized |
16.315 |
* |
4.564 |
*** |
1.445E+09 |
|
7.116 |
*** |
| Cold Ischemia Time |
|
|
|
|
|
|
|
|
| 0 to < 15 hours |
Reference |
|
|
Reference |
|
|
| 15 to < 20 hours |
1.029 |
|
|
|
0.251 |
|
|
|
| 20 to < 26 hours |
0.888 |
|
|
|
0.154 |
|
|
|
| 26+ hours |
1.838 |
|
|
|
0.000 |
|
|
|
| Unknown |
0.730 |
|
|
|
0.313 |
|
|
|
| Year |
|
|
|
|
|
|
|
|
| 2000 |
Reference |
|
|
Reference |
|
|
| 2001 |
1.022 |
|
|
|
0.719 |
|
|
|
| 2002 |
0.719 |
|
|
|
0.219 |
|
|
|
| 2003 |
0.553 |
|
|
|
0.026 |
|
|
|
| 2004 |
0.688 |
|
|
|
0.074 |
|
|
|
| 2005 |
0.429 |
|
|
|
0.555 |
|
|
|
| 2006 |
1.352 |
|
|
|
1.764 |
|
|
|
| 2007 |
0.000 |
|
|
|
0.000 |
|
|
|
| Length of Stay |
1.128 |
*** |
1.105 |
*** |
1.118 |
* |
1.085 |
* |
* P-value < 0.05
** P-value < 0.01
*** P-value < 0.001 |