|
Patient Death |
Graft Failure |
Variable |
Odds Ratio |
95% CI |
Odds Ratio |
95% CI |
| DGF– dialysis 1st week only |
1.24 |
(1.17 - 1.32)* |
1.24 |
(1.18 - 1.3) * |
| DGF– dialysis in 2 periods† |
1.60 |
(1.45 - 1.78) * |
1.66 |
(1.53 - 1.8) * |
| DGF– dialysis in more than 2 periods† |
2.08 |
(1.83 - 2.36) * |
2.23 |
(2.02 - 2.47) * |
| No DGF – some dialysis |
1.61 |
(1.44 - 1.8) * |
1.54 |
(1.41 - 1.69) * |
| No DGF – no dialysis |
Reference |
Reference |
| Recipient characteristics |
|
|
|
|
| Female |
0.92 |
(0.87 - 0.97) * |
0.91 |
(0.87 - 0.95) * |
| Race |
|
|
|
|
| African American |
0.94 |
(0.88 - 1.01) * |
1.27 |
(1.21 - 1.33) * |
| White |
Reference |
|
Reference |
|
| Other |
0.70 |
(0.61 - 0.8) * |
0.79 |
(0.71 - 0.88) * |
| Age (years) |
|
|
|
|
| 18-30 |
Reference |
|
Reference |
|
| 31-44 |
1.41 |
(1.21 - 1.63) * |
0.86 |
(0.8 - 0.94) * |
| 45-59 |
2.17 |
(1.88 - 2.5) * |
0.86 |
(0.79 - 0.93) * |
| > 60 |
3.38 |
(2.93 - 3.89) * |
1.06 |
(0.98 - 1.16) |
| BMI category (kg/m2) |
|
|
|
|
| < 10 or Missing |
1.01 |
(0.95 - 1.08) |
1.04 |
(0.99 - 1.1) |
| >10 to <25 |
Reference |
|
Reference |
|
| > 25 to <30 |
0.91 |
(0.85 - 0.98) * |
0.95 |
(0.9 - 1.01) |
| > 30 |
1.02 |
(0.94 - 1.11) |
1.09 |
(1.02 - 1.16) * |
| Primary cause of ESRD |
|
|
|
|
| Diabetes mellitus |
1.55 |
(1.41 - 1.7) * |
1.19 |
(1.1 - 1.28) * |
| Hypertension |
1.05 |
(0.95 - 1.16) |
1.07 |
(0.99 - 1.15) |
| Glomerulonephritis |
0.81 |
(0.73 - 0.9) * |
0.90 |
(0.83 - 0.98) * |
| PKD |
0.66 |
(0.58 - 0.76) * |
0.70 |
(0.63 - 0.78) * |
| Other |
Reference |
|
Reference |
|
| Unknown |
1.00 |
(0.89 - 1.12) |
1.02 |
(0.93 - 1.11) |
| Hispanic |
1.49 |
(1.36 - 1.63) * |
1.24 |
(1.16 - 1.33) * |
| PVD |
1.32 |
(1.19 - 1.46) * |
1.24 |
(1.13 - 1.36) * |
| Pre-Transplant Dialysis |
|
|
|
|
| None (pre-emptive) |
0.96 |
(0.84 - 1.11) |
0.92 |
(0.83 - 1.03) |
| 0-12 months |
Reference |
|
Reference |
|
| 13-24 months |
1.02 |
(0.92 - 1.14) |
1.00 |
(0.92 - 1.08) |
| 25-60 months |
1.00 |
(0.92 - 1.1) |
0.94 |
(0.87 - 1.01) |
| More than 60 months |
1.15 |
(1.03 - 1.28) * |
1.00 |
(0.92 - 1.09) |
| Donor Characteristics |
|
|
|
|
| Female |
1.03 |
(0.98 - 1.09) |
1.08 |
(1.04 - 1.13) * |
| Race |
|
|
|
|
| African American |
1.08 |
(0.99 - 1.17) |
1.18 |
(1.11 - 1.26) * |
| White |
Reference |
|
Reference |
|
| Other |
0.98 |
(0.84 - 1.14) |
1.00 |
(0.89 - 1.13) |
| Age (years) |
|
|
|
|
| ≤ 18 |
1.03 |
(0.94 - 1.12) |
1.03 |
(0.96 - 1.1) |
| 19-30 |
Reference |
|
Reference |
|
| 31-44 |
1.05 |
(0.97 - 1.13) |
1.10 |
(1.03 - 1.17) * |
| 45-59 |
1.17 |
(1.07 - 1.26) * |
1.25 |
(1.17 - 1.34) * |
| ≥ 60 |
1.19 |
(1.04 - 1.36) * |
1.44 |
(1.29 - 1.6) * |
| BMI category (kg/m2) |
|
|
|
|
| < 10 or Missing |
0.97 |
(0.86 - 1.1) |
1.01 |
(0.91 - 1.11) |
| >10 to <25 |
Reference |
|
Reference |
|
| > 25 to <30 |
0.94 |
(0.88 - 1) |
0.95 |
(0.9 - 1) |
| > 30 |
1.01 |
(0.94 - 1.09) |
0.95 |
(0.9 - 1.01) |
| Death due to stroke |
1.09 |
(1.02 - 1.16) * |
1.11 |
(1.05 - 1.17) * |
| Terminal Creatinine ≥ 1.5 |
0.94 |
(0.87 - 1.01) |
1.01 |
(0.96 - 1.08) |
| Hypertension history |
1.02 |
(0.95 - 1.1) |
1.06 |
(1 - 1.13) * |
| Diabetes |
1.14 |
(1 - 1.29) * |
1.16 |
(1.04 - 1.28) * |
| Transplant Factors |
|
|
|
|
| Donor Type |
|
|
|
|
| SCD |
Reference |
|
Reference |
|
| ECD |
1.19 |
(1.06 - 1.33) * |
1.10 |
(1.01 - 1.2) * |
| DCD |
1.07 |
(0.88 - 1.3) |
1.02 |
(0.87 - 1.19) |
| Peak PRA % |
|
|
|
|
| 0-10% |
Reference |
|
Reference |
|
| 11-30% |
1.02 |
(0.94 - 1.1) |
1.07 |
(1 - 1.14) |
| >30% |
1.19 |
(1.1 - 1.28) * |
1.22 |
(1.15 - 1.3) * |
| Unknown |
1.19 |
(1.01 - 1.42) * |
1.10 |
(0.95 - 1.26) |
| HLA Mismatches |
|
|
|
|
| 0 HLA mismatches |
Reference |
|
Reference |
|
| 1 HLA mismatches |
1.09 |
(0.96 - 1.25) |
1.08 |
(0.97 - 1.22) |
| 2 HLA mismatches |
1.10 |
(0.97 - 1.23) |
1.18 |
(1.07 - 1.3) * |
| 3 HLA mismatches |
1.16 |
(1.04 - 1.29) * |
1.22 |
(1.11 - 1.33) * |
| 4 HLA mismatches |
1.18 |
(1.06 - 1.32) * |
1.30 |
(1.19 - 1.42) * |
| 5 HLA mismatches |
1.21 |
(1.08 - 1.35) * |
1.29 |
(1.17 - 1.41*) |
| 6 HLA mismatches |
1.22 |
(1.06 - 1.4) * |
1.34 |
(1.2 - 1.5) * |
| Unknown |
1.20 |
(1 - 1.45) * |
1.27 |
(1.09 - 1.47) * |
| CMV sero-pairing |
|
|
|
|
| Donor - / Recipient - |
Reference |
|
Reference |
|
| Donor - / Recipient + |
1.15 |
(1.04 - 1.27) * |
1.12 |
(1.03 - 1.21) * |
| Donor + / Recipient - |
1.27 |
(1.15 - 1.42) * |
1.24 |
(1.14 - 1.35) * |
| Donor + / Recipient + |
1.23 |
(1.11 - 1.35) * |
1.16 |
(1.08 - 1.25) * |
| Unknown |
1.21 |
(1.07 - 1.36) * |
1.17 |
(1.06 - 1.28) * |
| Cold-time |
|
|
|
|
| 0 - 14 hours |
Reference |
|
Reference |
|
| 15 - 19 hours |
0.99 |
(0.92 - 1.07) |
1.02 |
(0.96 - 1.08) |
| 20 - 25 hours |
1.07 |
(1 - 1.16) |
1.11 |
(1.05 - 1.18) * |
| 26+ hours |
1.05 |
(0.97 - 1.13) |
1.07 |
(1.01 - 1.14) * |
| Unknown |
1.01 |
(0.9 - 1.13) |
1.03 |
(0.95 - 1.13) |
| Year |
|
|
|
|
| 1995 |
|
|
Reference |
|
| 1996 |
0.94 |
(0.85 - 1.03) |
0.94 |
(0.87 - 1.02) |
| 1997 |
0.99 |
(0.9 - 1.09) |
0.95 |
(0.88 - 1.02) |
| 1998 |
1.01 |
(0.91 - 1.11) |
0.95 |
(0.88 - 1.02) |
| 1999 |
0.99 |
(0.89 - 1.1) |
0.92 |
(0.85 - 1) |
| 2000 |
1.09 |
(0.97 - 1.21) |
1.02 |
(0.94 - 1.11) |
| 2001 |
1.04 |
(0.92 - 1.17) |
0.92 |
(0.84 - 1.01) |
| 2002 |
0.96 |
(0.83 - 1.1) |
0.96 |
(0.86 - 1.06) |
| 2003 |
0.96 |
(0.82 - 1.14) |
0.90 |
(0.79 - 1.03) |
| 2004 |
0.92 |
(0.7 - 1.22) |
0.90 |
(0.73 - 1.12) |
* P-value < 0.05
†Periods of early dialysis were first week, the second week, weeks 3 or 4, the second month and the third month post-transplant |
