Identified Proteins Accession # Cellular Function
4-trimethylaminobutyraldehyde dehydrogenase (ALDH) gi|62511242 Catalyzes the irreversible oxidation of aldehydes to the corresponding acids in an NAD-dependent reaction. Stem cell marker
Annexin VI isoform 1 gi|71773329 Mediates the intracellular calcium Signal
ATP synthase, beta subunit precursor gi|32189394 ATP synthesis
Dipeptidyl peptidase III gi|18491024 Protease that is a member of the S9B family. Increased activity of this protein is associated with endometrial and ovarian cancers.
Elongation factor Tu, mitochondrial precursor (EF-Tu) gi|1706611 Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein synthesis.
Enolase 1 gi|4503571 Myc promoter-binding protein
Eukaryotic translation elongation factor 2 gi|4503483 Essential factor for protein synthesis
Heat shock 70kDa protein 5 gi|16507237 Cellular stress response
Heat shock 70kDa protein 8 isoform 1 gi|5729877 Cellular stress response
L-plastin gi|4504965 Actin-binding proteins expressed only in hemopoietic cell lineages in benigh tissue, but in malignant human cells of nonhemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
Macrophage Migration Inhibitory Factor (Mif) gi|13399777 Inhibits macrophage migration and causes adherence
Mutated melanoma-associated antigen 1 gi|152032608 Melanoma-associated antigen
Proteasome (prosome, macropain) subunit, alpha type 6 gi|8394076 Central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus
Proteasome subunit, α5 gi|7106387 Protein degradation
Protein disulfide isomerase-associated 3 precursor gi|21361657 Endoplasmic reticulum protein interacting with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins
Protein disulfide isomerase-associated 4 gi|4758304 Catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the endoplasmic reticulum
Pyruvate kinase 3 isoform 1 gi|33286418 (+2) Catalyzes the rate-limiting step of glycolysis
Thioredoxin peroxidase gi|5453549 Antioxidant enzyme belongs to the peroxiredoxin family. Reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol. Regulate the activation of the transcription factor NF-kappaB
Tumor rejection antigen (gp96) 1 gi|4507677 Cellular stress response
Vesicle amine transport protein 1 gi|18379349 An abundant integral membrane protein involved in vesicular transport
Table 4A: Selected over-expressed proteins (≥ 2 fold) in a triple negative breast cancer (TNBC, Case A) tumor when compared with a hormone-receptor-positive- Her2-negative (Non-TNBC, Case B) tumor specimen.