Base position

Hatay/2004

Change in properties

Sec. structure

Hydrophobicity (Kyte & Doolittle)

Neuraminidase

240

T->A

Hydrophilic, Polar ->Hydrophobic

Strand

0.622 -> 0.900

451

G ->S

Hydrophobic -> Hydrophilic, Polar

Coil

-0.167 ->-0.211

Hemagglutinin

225

R ->K

Hydrophilic ->Hydrophilic

Coil

-2.289 -> -2.222

283

I ->V

Hydrophobic ->Hydrophobic

Strand

1.044 -> 1.011

Table 2: Amino acid mutations in neuraminidase and hemagglutinin at specific position and change in properties, secondary structure and hydrophobicity.