ProPred 1 (MHCI)

TCL epitope sequences

Amino acid position

No of MHC I binding alleles

YSCPVLNGK

182

9

KGLPGIHII

191

15

CPVLNGKGL*

185

23

GKGLPGIHI

190

2

LPGIHIIPA

193

10

ProPred (MHCII)

HCL epitope sequences

Amino acid position

No of MHC II binding alleles

LNGKGLPGI

188

2

LPGIHIIPA

193

4

VLNGKGLPG

187

1

Table 2: T-cell epitopes of N. gonorrhoeae ddl. The common antigenic B-cell epitope “EYSCPVLNGKGLPGIHIIPAT” was analyzed for its ability to bind MHC I and MHC II molecules using Propred I and Propred. A common epitope “LPGIHIIPA” (9 mers) that generates both TCL and HCL mediated immune response was selected. Peptides those contain proteosomal cleavage site are marked with an asterisk (*).