Major homozygote

  Minor homozygote1

Heterozygote2

 

MOI

 

ΨAA

Pr(case/aa)

Ψaa = ____________

Pr(case/AA)

Pr(case/aA)

ΨaA = ____________

Pr(case/AA)

Recessive

1

Φ

1

Dominant

1

Φ

Φ

Additive

1

2*Φ-1

Φ

Multiplicative

1

Φ *Φ

Φ

1Ψaa is the relative risk of homozygous minor to homozygous majors
2Ψaa is the relative risk of heterozygote to homozygous major
Table 1: Relative Risk assumptions by MOI, see Iles (2002).