Figure 6: Association of nuclear peptidyl Cys with functional networks according to reduction and oxidation of Cys residues. Percent reduction values for the 36 most reduced Cys (Panel A) and the 36 most oxidized Cys (Panel B) were analyzed by Ingenuity Pathway Analysis. In A, the reduced nuclear peptides had network functions associated with molecular transport and RNA post-transcriptional modification (Score 26). In B, The most oxidized nuclear peptides showed functional networks associated with poly-ADP-ribose, caspase and histones H3 and H4 (Score 35). Abbreviations: ANP32B, acidic leucine-rich nuclear phosphoprotein 32 family member B; CASC3, cancer susceptibility candidate 3; CLIC1, chloride intracellular channel 1; CSE1L, chromosome segregation 1-like; DDX5, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DDX17, DEAD box polypeptide 17; DDX39, DEAD box polypeptide 39; HNRNPA3, heterogeneous nuclear ribonucleoprotein A3; HNRNPAB, heterogeneous nuclear ribonucleoprotein AB; HNRNPA2B1, heterogeneous nuclear ribonucleoprotein A2/B1; HNRNPD, heterogeneous nuclear ribonucleoprotein D; HNRNPH2, heterogeneous nuclear ribonucleoprotein H2; HNRNPL, heterogeneous nuclear ribonucleoprotein L; H2AFY, core histone macro- H2A.1; IPO5, importin 5; IPO7, importin 7; LMNB1, lamin B1; MCM2, minichromosome maintenance complex component 2; NXT1, NTF2-like export factor 1; NUMA1, nuclear mitotic apparatus protein 1; PCBP1, poly(rC) binding protein 1; PCNA, proliferating cell nuclear antigen; PRKDC, protein kinase, DNA-activated, catalytic polypeptide; RAN, GTP-binding nuclear protein; RBM42, RNA binding motif protein 42; THOC1, THO complex 1; TRAP/Media, regulator for estrogen receptor signaling; WBP11, WW domain binding protein 11; XPOT, exportin.