Figure 7: Association of mitochondrial peptidyl Cys with functional networks according to reduction and oxidation of Cys residues. Percent reduction values for Cys more reduced than average (Panel A) and more oxidized than average (Panel B) were analyzed by Ingenuity Pathway Analysis. In A, more reduced peptides (n=24) associated with functional networks of lipid metabolism, small molecule biochemistry and cancer (Score 39). In B, more oxidized peptides (n=13) associated with cellular function and maintenance (Score 36). Abbreviations: ADCYAP1, adenylate cyclase activating polypeptide 1; ECHS1, short-chain enoyl-CoA hydratase; ETFA, electron-transferring flavoprotein-A; ETFB, electron-transferring flavoprotein-B; GLUD1, glutamate dehydrogenase-1; GOT2, aspartate aminotransferase-2; HK1, hexokinase-1; IDH2, isocitrate dehydrogenase-2; MDH2, malate dehydrogenase-2; MGST1, microsomal glutathione-S-transferase-1; MTCH2, mitochondrial carrier homolog-2; NDUFAB1, NADH-ubiquinone oxidoreductase subunit AB1 (ACPM, acyl carrier protein, mitochondrial); SHMT2, serine hydroxymethyltransferase-2; SLC25A4, solute carrier family 25-A4 (adenine nucleotide translocase-1, ANT1); SDHA, succinate dehydrogenase subunit A; SDHC, succinate dehydrogenase subunit C; TBK1, TANK-binding kinase 1; TUFM, mitochondrial translational protein Tu; UQCRB, ubiquinol-cytochrome c reductase binding protein; UQCRC1, ubiquinol-cytochrome c reductase core protein 1; UQCRC2, ubiquinol-cytochrome c reductase core protein 2; UQCRQ, ubiquinol-cytochrome c reductase, complex III subunit VII.