Protein

CYS

Hum

Oran

Bovin

Rat

Mous

Chick

X. trop

X laev

D rerio

S salar

Total

Cons

%Cys cons

Ten most reduced peptides

SDHA

536

+

+

+

+

+

+

+

+

+

+

10

10

100

ACTB

285

+

+

+

+

+

+

+

+

+

+

10

10

100

RPL3

114

+

0

+

+

+

+

+

+

+

+

9

9

100

PKM2

473

+

+

+

+

+

0

-

+

-

-

9

6

67

MDH2

89

+

+

+

+

+

+

-

-

-

-

10

6

60

EEF2

290

+

+

+

+

+

+

+

0

-

-

9

7

78

RAC1

105

+

0

+

+

+

+

+

+

+

+

9

9

100

DDX39

197

+

0

+

+

+

+

+

+

+

+

9

9

100

HNRNPD

126

+

0

+

+

+

+

+

+

+

+

9

9

100

XRCC5

489

+

+

+

+

+

0

0

+

+

0

7

7

100

Ten most oxidized peptides

HSP90AB1

410

+

+

+

+

+

+

+

+

+

+

10

10

100

CD59

70

+

+

+

+

+

+

0

0

0

+

7

7

100

LAP3

462

+

0

+

+

+

+

+

+

+

+

9

9

100

HNRNPR

226

+

+

+

+

+

+

-

-

+

+

10

8

80

HSP90AA1

420

+

+

+

+

+

+

+

+

+

+

10

10

100

FASN

212

+

0

+

+

+

+

0

0

0

0

5

5

100

NOP56

384

+

+

+

+

+

+

+

+

+

-

10

9

90

RAC1

6

+

+

+

+

+

+

+

+

+

+

10

10

100

EPCAM

99

+

0

+

+

+

+

+

+

+

+

9

9

100

EIF2S3

236

+

+

+

+

+

+

+

+

+

+

10

10

100

Ten randomly selected from measured peptides

DDT

24

+

0

+

+

+

+

+

+

+

+

9

9

100

PKM2

358

+

+

+

+

+

+

+

+

+

+

10

10

100

GBLP

207

+

0

+

+

+

+

+

+

+

+

9

9

100

AL1A1

186

+

+

+

+

+

+

+

+

+

+

10

10

100

ALDOC

178

+

+

+

+

+

0

+

+

+

+

9

9

100

AAAT

467

+

0

+

+

+

0

+

+

+

0

7

7

100

NASP

708

+

0

+

+

+

+

+

+

-

-

9

7

78

IMB1

158

+

0

+

+

+

0

0

+

0

0

5

5

100

GCN1L

648

+

0

0

0

+

0

0

0

-

0

3

2

67

PARK7

53

+

0

+

+

+

+

+

+

+

+

9

9

100

Avg % for proteins                        

94

Avg % for species

100

100

100

100

100

100

86

92

80

80

261

246

94

*Abbreviations: AAAT, neutral amino acid transporter B(0); ACTB, beta-actin; AL1A1, retinal dehydrogenase 1 (aldehyde dehydrogenase family 1 member A1); ALDOC, fructose-bisphosphate aldolase C; CD59, CD59 glycoprotein; DDX39, DEAD box polypeptide 39; DDT, D-dopachrome decarboxylase (D-dopachrome tautomerase), EEF2, elongation factor 2; EIF2S3, eukaryotic translation initiation factor 2 subunit 3; EPCAM, epithelial cell adhesion molecule; LAP3, cytosol aminopeptidase; FASN, fatty acid synthase; GBLP, guanine nucleotide-binding protein subunit beta-2-like 1; GCN1L, translational activator GCN1; HNRNPD, heterogeneous nuclear ribonucleoprotein D; HNRNPR, heterogeneous nuclear ribonucleoprotein R; HSP90AA1, heat shock protein HSP 90-alpha; HSP90AB1, HSP90AB1 protein; IMB1, importin subunit beta-1 (karyopherin subunit beta-1); MDH2, malate dehydrogenase-2; NASP, nuclear autoantigenic sperm protein; NOP56, nucleolar protein 56; PARK7, protein DJ-1 (Parkinson disease protein 7); PKM2, pyruvate kinase isozymes M1/M2; RAC1, Ras-related C3 botulinum toxin substrate 1; RPL3, 60S ribosomal protein L3; SDHA, succinate dehydrogenase subunit A; XRCC5, X-ray repair cross-complementing protein 5
Table 1: Conservation among vertebrates of most reduced and most oxidized peptidyl Cys*.