Figure 5: Downregualtion of SMARCA4 in MTLE. A-B: Control hippocampus showing diffuse labeling of dentate gyrus granule neurons (A) (Obj x 40), and pyramidal neurons of Ammon’s horn (B) (Obj x 40). C-D: Hippocampus from a case of mesial temporal sclerosis showing absent expression in dentate granule neuron (C) (Obj x 40) is compared to control. Light cytoplasmic labeling of pyramidal neurons and nuclear labeling of scattered glial cells seen in temporal cortex (D) (Obj x 20), markedly downregulated compared to controls.