Sl. No

Gene Symbol

Protein

Features

Fold change

p-value

1

CLEC18A

C-type lectin domain family 18, member A

Localized extracellularly,

+4.3

0.0000018

2

ARL11

ADP-ribosylation factor-like 1

Play a role in caspase dependant apoptosis

+3.9

0.000087

3

GALNT5

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5

Transmembrane protein shown to be expressed in body fluids such as tears

+3.1

0.001

4

ADAMTS15

ADAM metallopeptidase with thrombospondin type 1 motif, 15

Known to be localized extracellularly could detect in body fluids

+3.0

0.00019

5

BMPR1B

Bone morphogenetic protein receptor, type I

A serine/threonine kinase with primary localization of plasma membrane. It also has tranmembrane domain.

+2.7

0.0025

6

CLDN11

Claudin 11

An integral membrane protein and a marker for oligo dendrocytes

+2.5

0.021

7

SC4MOL

Sterol-C4-methyl oxidase-like

A transmembrane protein localized to endoplasmic reticulum and also involved in lipid synthesis

+2.2

0.0037

8

IL20RB

Interleukin 20 receptor beta

A heterodimeric receptor for interleukin-20, which is associated with inflammation

+2.2

0.00024

9

PPBP

Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)

Localized extracellularly and a chemo attractant.

+2.2

0.02

10

STK31

Serine/threonine kinase 31

A kinase with a tudor domain.

+2.0

0.014

11

SPINK4

Serine peptidase inhibitor, Kazal type

Localized extracellularly and known to regulate GABA release

-3.1

0.000036

12

TYMP

Thymidine phosphorylase

Localized extracellularly and know to be secreted in body fluids such as tears.

-2.9

0.00013

13

STOML3

Stomatin (EPB72)-like 3

A transmembrane protein localized to plasma membrane

-2.7

0.0041

14

TPTE2

Transmembrane phosphoinositide 3-phosphatase and tensin homolog

A membrane associated  phosphoinositide 3-phosphatase

-2.7

0.000069

15

SMARCA4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Transcription regulator and associated with neurogenesis

-2.3

0.00023

Table 2: A partial list of differentially expressed genes in MTLE.