Gene symbol Gene description Host-bacteria interaction
WB-A WB-B WB-M S-A S-B
CRP C-reactive protein, pentraxin-related 1.6 (ns) ns (ns) -2.0 (-3.3 ± 0.01) ns (ns) ns (ns)
CD247 CD247 molecule 1.6 (ns) -2.2 (ns) ns (ns) ns (ns) ns (ns)
CD3D CD3d molecule, delta (CD3-TCR complex) ns (ns) ns (ns) 2.1 (ns) -2.2 (ns) ns (ns)
CD4 CD4 molecule 1.4 (ns) ns (ns) ns (ns) 1.3 (ns) ns (ns)
CD74 CD74 molecule, major histocompatibility complex. ns (ns) -4.1 (ns) -3.3 (-5.3 ± 0.2) ns (ns) ns (ns)
KITLG KIT ligand 3.2 (ns) ns (ns) ns (ns) -1.2 (ns) ns (ns)
CALCR Calcitonin receptor 5.3 (ns) 3.7 (ns) ns (ns) ns (ns) ns (ns)
CCR4 Chemokine (C-C motif) receptor 4 ns (1.9±0.02) ns (ns) -2.3 (-8.1±0.05) -1.4 (ns) 3.0 (ns)
CXCL12 Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 1.4 (ns) -4.8 (ns) -9.8 (-2.5±0.02) -2.7 (-4.5±2E-3) ns (-11.1±8E-6)
CSF2 Colony stimulating factor 2 (granulocyte-macrophage) 1.4 (ns) ns (ns) ns (ns) 1.6 (6.1±4E-4) ns (-4.2±4.5-6)
C1QA Complement component 1, q subcomponent, A chain 1.3 (ns) -2.8 (ns) ns (-3.7 ± 0.2) ns (ns) ns (ns)
C1qB Complement component 1, q subcomponent, B chain 1.3 (ns) -3.9 (ns) -9.0 (ns) ns (ns) ns (ns)
C5 Complement component 5 1.5 (ns) ns ns ns ns 1.3 (8.0±4E-4) ns (-10.0±2E-6)
C7 Complement component 7 2.5 (ns) ns (ns) ns (ns) 1.3 (ns) ns (ns)
FTH1 Ferritin, heavy polypeptide 1 ns (ns) -3.6 (ns) -4.1 (-2.5±0.7) ns (ns) ns (ns)
HMOX1 Heme oxygenase (decycling) 1 ns (ns) -2.5 (ns) -1.7 (-2.5±0.1) ns (ns) ns (ns)
HIF1A Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.3 (ns) -2.0 (-3.0±0.02) ns (ns) ns (ns) ns (ns)
IL1B Interleukin 1, Beta ns (ns) 2.9 (ns) ns (ns) 1.3 (2.3±3E-4) 2.1 (1.4±5E-5)
IL15 Interleukin 15 ns (ns) ns (ns) ns (ns) 1.2 (ns) 2.7 (ns)
IL21 Interleukin 21 1.3 (ns) ns (ns) ns (ns) 1.2 (ns) ns (ns)
IL25 Interleukin 25 ns (ns) ns (ns) ns (ns) 1.3 (ns) 1.6 (ns)
IL4R Interleukin 4 receptor 1.2 (ns) ns (ns) ns (ns) -2.0 (ns) ns (ns)
IL5 Interleukin 5 (colony-stimulating factor, eosinophil) 1.3 (ns) ns (10.8 ± 0.5) ns (-3.1±3E-4) ns (ns) 2.6 (ns)
IL6 Interleukin 6 (interferon, beta 2) 2.0 (ns) ns (ns) ns (ns) 1.2 (ns) ns (1.1±4E-6)
IL9 Interleukin 9 ns (ns) ns (ns) ns (ns) 1.3 (ns) 1.3 (ns)
MIF Macrophage migration inhibitory factor (glycosylation-inhibiting factor) ns (ns) ns (ns) ns (ns) -2.0 (ns) 10.4 (ns)
MSN Moesin ns (ns) -2.6 (ns) -3.4 (ns) ns (ns) ns (ns)
PPARG Peroxisome proliferator-activated receptor gamma 1.2 (ns) -3.5 (ns) ns (ns) ns (ns) ns (ns)
PSME1 Proteasome (prosome, macropain) activator subunit 1 ns (3.4 ± 2) -3.1 (ns) -2.4 (-3.5 ± 2.8) ns (ns) ns (ns)
RGS1 Regulator of G-protein signaling 1 ns (ns) -2.0 (ns) -1.9 (ns) ns (ns) ns (ns)
SCG2 Secretogranin II (chromogranin C) 1.6 ± (ns) 2.1 (ns) ns (ns) ns (ns) ns (ns)
TLR8 Toll-like receptor 8 ns (ns) -2.4 (ns) ns (-2.72 ± 0.2) 1.2 (ns) ns (ns)
VCAM1 Vascular cell adhesion molecule 1 1.6 (-3.2±0.02) -4.8 (ns) ns (-2.5± 0.2) ns (ns) ns (ns)
FADD Fas (TNFRSF6)-associated via death domain 1.2 (ns) ns (ns) -10.8 (-2.8±0.6) ns (ns) ns (ns)
COL5A1 Collagen, type V, alpha 1 1.4 (ns) -2.5 (ns) ns (ns) ns (ns) ns (ns)
CTGF Connective tissue growth factor 1.3 (1.3±0.3) -2.8 (ns) ns (ns) ns (ns) ns (ns)
DMP1 Dentin matrix acidic phosphoprotein 1 1.2 (ns) 1.9 (3.6±0.05) ns (ns) ns (ns) ns (ns)
FGF2 Fibroblast growth factor 2 (basic) 1.6 (ns) ns (ns) ns (-3.1±2E-3) 1.3 (ns) 1.6 (ns)
FGF7 Hypothetical fibroblast growth factor 7 (keratinocyte growth factor) 1.4 (ns) ns (ns) ns (-2.6±0.1) 1.2 (1.9±7E-5) ns (1.9±2E-5)
STC1 Stanniocalcin 1 1.4 (ns) 2.2 (12.1±0.01) ns (ns) ns (ns) ns (ns)
TGFB3 Transforming growth factor, beta 3 1.3 (7.3±3E-4) ns (ns) ns (ns) ns (ns) 3.2 (1.8 ± 4E-6)
TKY2 Tyrosine kinase 2 ns (ns) -1.9 (ns) -2 (-2.4±0.03) ns (ns) ns (ns)
EPOR Ethropoietin receptor 1.4 (ns) ns (ns) ns (ns) 1.8 (ns) ns (ns)
IL15RA Interleukin 15 receptor, alpha ns (ns) ns (ns) ns (ns) 1.4 (ns) -1.6 (ns)
Data shows significant (P<0.05) fold change in differential gene expression (positive and negative values for upregulated and downregulated genes in infected animals, respectively) obtained in the microarray analyses and by real-time RT-PCR (shown in parenthesis; average±SD). Abbreviations: ns, not significant differences in gene expression levels between infected and uninfected animals; WB-A, wild boar infected with A. phagocytophilum; WB-B, wild boar infected with B. suis; WB-M, wild boar infected with M. bovis; S-A, sheep infected with A. phagocytophilum; S-B, sheep infected with B. ovis
Table 4: Differential expression of genes in common host-cell biological processes, molecular functions and pathways affected by pathogenic intracellular bacteria.