Spot No. Top ranked protein name Gene Name NCBI Accession No. MW (Da) (pI) MASCOT Score p-value Fold change Proteins with increased levels 22 Synuclein α Snca GI9507125 14506.2 (4.74) 279 0.006 1.34 10 Hexokinase Type I, Chain B, rat brain Hk1 GI5542104 102455.2 (6.29) 223 0.00023 1.31 21 Proteasome (prosome, macropain) subunit, β type 2 Psmb2 GI34849630 22897.7  (6.96) 176 0.014 1.27 24 Endosulfine α Ensa GI9624979 13326.7 (6.62) 127 0.016 1.26 11 TNF receptor-associated protein 1 Trap1 GI55741837 80410.8 (6.56) 99 0.025 1.26 Proteins with decreased levels 25 EGF-containing fibulin-like extracellular matrix protein 2 Efemp2 GI53733803 44820.3 (4.79) 33 0.046 -1.78 19 Synaptosomal-associated 25kD protein Snap25 GI57114057 23300.2 (4.66) 213 0.034 -1.70 1 2'-5' oligoadenylate synthetase 1H Oas1h GI57222310 42800.7 (5.38) 39 0.024 -1.49 12 Calreticulin Calr GI11693172 47965.8 (4.33) 343 0.017 -1.47 2* Microtubule-associated protein 2 Map2 GI547890 202287.6 (4.77) 103 0.007 -1.45 3* Microtubule-associated protein 2 Map2 GI56625                198445.6 (4.76) 226 0.036 -1.38 23 Similar to diphosphoinositol polyphosphate phosphohydrolase Nudt3 GI27704734 19083.6 (6.00) 36 0.0011 -1.38 15 Laminin receptor 1/Ribosomal protein SA Rpsa GI8393693 32803.4 (4.8) 204 0.04 -1.36 17 Clathrin, light chain B Cltb GI16758690 25102.1 (4.56) 269 0.015 -1.35 13 Growth associated protein 43 Gap43 GI8393415 23589.3 (4.61) 40 0.035 -1.35 9 Brain abundant, membrane attached signal protein 1 Basp1 GI11560135 21777.4 (4.5) 70 0.0097 -1.32 7 Valine t-RNA synthetase Vars GI484949 66744 (6.19) 42 0.024 -1.32 16 2',3'-cyclic nucleotide 3'-phosphodiesterase Cnp GI294527 47238.6 (9.03) 48 0.012 -1.29 18 Glyceraldehyde-3-phosphate dehydrogenase Gapdh GI8393418 35805.2 (8.14) 152 0.0038 -1.27 Note: *Spot 2 represents a phosphorylated form of Map2

Table 2: List of differentially expressed proteins in rat PFC after chronic lithium treatment.