Network ID Molecules in Network Scores Focus Molecules Top Functions 1 AKT1, AKT2, RTK, AMPK, ATM/ATR, BRCA1, CDC2, CDC25A, Cdc25B/C, CDC25C, CDK2, CDKN1B, CHEK1, CHEK2,Cyclin A, Cyclin B, Cyclin D, Cyclin E, E2f, Fcer1, Foxo, Ige, Laminin, LIMK1, MAP2K2, MAP2K3, MEF2, Mek,Pkg, PRKAA1, RAF1, Rb, RB1, Scf, STMN1 31 19 Cancer, Cell cycle 2 Actin, Alpha Actinin, Beta Arrestin, Calpain, CAV1,CFL1, Cofilin, Collagen(s), CTTN, Dynamin, Erm, EZR, F Actin, FAK-Src, FCGR1A/2A/3A, G3BP1, Integrin alpha V beta 3, KRT18, MAP2K1/2, NF2, NTRK2, Pak, phosphatase, PTEN, PTK2, PXN, Rac, Ras homolog, Rock, SRC, Talin, VASP 26 20 Cellular Movement, Cell Morphology 3 AKT1, ALP, Calmodulin, CaMKII, Caspase, CDKN1A, Ck2, Creb, CREB1, CTNNB1,Cytochrome c, ERBB2,ESR1, FSH, GLRX2, HDAC8,Histone h3, Histone h4, Hsp70, HSP84-2, HSP90AB1,ICAM1, JUN,Nfat, PDPK1, Pp2b, Proteasome, RNA polymerase II, Rxr, Smad, SYN1, TFIIH, Tubulin, YWHAZ 21 14 Cancer, Reproductive system disease Phosphorylation -specific antibody microarrays were used to monitor active and inactive protein levels in PC3 cells following CXCL13 stimulation. The resulting profiles were analyzed and clustered in eight different networks and the focus molecules of each network are written in bold. Score was derived from a p-value and indicates the probability of the involvement of focus molecule(s) in a given network. Focus molecules in each network represent proteins on the array exhibited increases in phosphorylation.

Table 1: Highest scoring networks involved in CXCL13-treated metastatic prostate cancer.